Thrombocytopenia (low platelet count) - Symptoms and causes - Mayo Clinic
Objective The aim of the research was to investigate the relationship between gastric cancer stage, prognosis and blood platelets count. Having a high blood platelet count is a strong predictor of cancer and the association between thrombocytosis and undiagnosed cancer. In rare cases, the number of platelets may be so low that dangerous Sometimes it can occur in association with a bacterial Escherichia coli.
In this review, we revisit the topic with the latest in accumulated evidence; evidence that clearly points to a role for platelet functions in the hemostatic microenvironment being subverted and employed by tumor cells to facilitate tumor progression, invasion, and metastasis. The ancient Mesopotamian, Egyptian, Greek, Roman, Indian, and Chinese physicians practiced bloodletting and often used the application of leeches to treat diseases until the practice reached its height in the s.Low Platelets: Causes, conditions and treatment
The use of leeches continues to the present following the Food and Drug Administration-approved use of Hirudo medicinalis in modern medicine [ 23 ]. The anticoagulant hirudin identified from leech saliva can help relieve venous insufficiency in skin and reattachment surgery [ 23 ]. Despite keen medical interest in blood over the ages, the crucial cellular components that contribute to clot formation were not readily identified. Even after the invention of the light microscope in by Dutch spectacle makers, Zaccharias and Hans Janssen descriptions of blood cells were not immediately forthcoming.
It was not until that Dutch biologist Jan Swammerdam identified red blood cells [ 45 ]. Nevertheless, the key subcellular factors were not described until A month later, William Addison published hand drawings of platelet—fibrin thrombus referring to them as extremely minute granules [ 6 ].
Examples of such conditions include: Thrombocytopenia caused by pregnancy is usually mild and improves soon after childbirth. This type is caused by autoimmune diseases, such as lupus and rheumatoid arthritis.
The body's immune system mistakenly attacks and destroys platelets. If the exact cause of this condition isn't known, it's called idiopathic thrombocytopenic purpura. This type more often affects children. Bacteria in the blood.
Severe bacterial infections involving the blood bacteremia may lead to destruction of platelets. This is a rare condition that occurs when small blood clots suddenly form throughout your body, using up large numbers of platelets. This rare disorder causes a sharp drop in platelets, destruction of red blood cells and impairment of kidney function. Be extra careful when using a knife or any type of sharp tool. Avoid getting burned when ironing or cooking.
Use oven mitts instead of pot holders to remove hot items from the oven. Check with your doctor before receiving any injections in the muscle intramuscular. Use pads instead of tampons during menstruation.
Do not use rectal suppositories, enemas or rectal thermometers. Avoid blowing the nose forcefully.
Avoid foods that are sharp, crunchy, spicy or acidic. Eat a soft diet, such as soup, mashed potatoes, custards, Jell-O or pudding. Do not drink alcohol. Drink plenty of fluids and eat enough fibre to avoid constipation.
Patients with high platelet counts should be tested for cancer
Avoid straining during bowel movements. If you are constipated, ask your doctor about taking a stool softener.
Talk to your healthcare team Do not take any over-the-counter medicines, such as pain relievers or cold remedies, without checking with the doctor first. These medicines may contain aspirin or other drugs that can weaken the platelets and make bleeding problems worse.
Managing bleeding Contact your healthcare team if any of the following bleeding problems get worse or cannot be controlled after 10 minutes.
Patients with high platelet counts should be tested for cancer | News | Pharmaceutical Journal
Nosebleeds If you get a nosebleed, sit up with your head tilted forward. Press a cold cloth on both sides of your nose continuously for 10 minutes.
You can also apply a cold cloth to the back of your neck. Bleeding of the gums or in the mouth If you can easily reach the bleeding area, apply gentle pressure until it stops. Bleeding from a cut Hold a clean dry cloth against the cut for at least 10 minutes. If possible, lift the injured body part above the level of the heart.