To examine incidence of AMD in a trial of folic acid/vitamin B6/vitamin B treatments for AMD as an important program goal for vision research (16). .. The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Folic acid and vitamin B12 in synthetic form are absorbed at about twice the efficiency as the food forms, especially in lower doses. . There is inadequate information on the relation- . mended that clear goals and target populations be set. Our goal in the present study was to determine whether higher folate status in serum folate interacted significantly with serum vitamin B12 in relation to . A high intake of folic acid in vitamin B12 deficiency would change the.
However, close study of the original case reports showed no proof that folic acid therapy exacerbated central nervous system CNS —related symptoms 1516and modern case reports and studies suggest that folic acid therapy did not cure anemia either 17 — Such data support the idea that folic acid can be safely added to foods in moderation, but recent editorials have stressed the need for systematic study of the hypothesis that high folate intakes cause harm 21 Data collected in the most recent National Health and Nutrition Examination Survey NHANES afforded us the opportunity to study interrelations between serum folate and vitamin B status in relation to anemia, macrocytosis, and cognitive impairment in the age of folic acid fortification.
The survey is currently implemented as a continuous annual survey and uses a complex multistage probability design to select a representative sample of the noninstitutionalized US civilian population. To increase the precision of estimates derived from the survey, adolescents, the elderly, Mexican Americans, and blacks are oversampled.
Consistent with NHANES analytic guidelines, we combined data from the 2 most recent surveys into a single data set — Trained interviewers used a computer-assisted personal interview system to interview participants in their homes.
The participants were also asked to report to a mobile examination center MEC to provide further interview data and undergo a physical examination that included phlebotomy.
Vitamin B12 And Folic Acid
Of senior survey participants, were eligible, were ineligible, and eligibility status could not be determined for Complete information for analyses pertaining to anemia was available for seniors, and complete information for analyses pertaining to cognitive function was available for seniors.
Assessment of anemia and macrocytosis Anemia and macrocytosis were assessed on the basis of hemoglobin concentrations and mean cell volumes, which were measured at the mobile examination center laboratory with a MAXM hematology flow cytometer Beckman Coulter Inc, Fullerton, CA.
Trop Med Int Health. Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission II.
Vitamin B12 And Folic Acid | Dr. Schweikart
Descriptive epidemiology of malaria infection and disease among children. Am J Trop Med Hyg.
Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria. Clinical and laboratory findings of Plasmodium vivax malaria in Colombia, Anaemia in childhood in the guinea savanna of Nigeria. Prevalence of anemia and deficiencies of iron, folic acid and vitamin B12 in an indigenous community from the Venezuelan Amazon with a high incidence of malaria.
Gamma interferon responses to Plasmodium falciparum liver-stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malaria. Methods for the detection of blood parasites.
Investigation and Management of Vitamin B12 and Folate Deficiency
Folate and vitamin B status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr. Erythrocyte defects and parasitemia density in patients with Plasmodium falciparum malaria in Buenaventura, Colombia. Rev Panam Salud Publica.
Clinical study of falciparum malaria in children in Manaus, AM, Brazil. Rev Soc Bras Med Trop. High prevalence of cobalamin deficiency in Guatemalan schoolchildren.B12 and Folate metabolism
Interrelationships of vitamin B 12, folic acid, and iron in anemia of infancy and childhood. Recent cross-sectional 17 — 19 and case-control 20 — 24 studies indicate a direct association between homocysteine concentration in the blood and risk of AMD, suggesting that homocysteine may be a modifiable risk factor for AMD. Homocysteine is an intermediary amino acid formed during the metabolism of methionine, an essential amino acid derived from protein Treatment with folic acid, vitamin B6 pyridoxineand vitamin B12 cyanocobalamin has been shown to reduce homocysteine levels in intervention studies 33and to reverse endothelial dysfunction independent of its homocysteine-lowering effect 34 However, trials of homocysteine-lowering among persons with pre-existing vascular disease provide little support for a benefit of supplemental folic acid and B vitamins in reducing cardiovascular events Nonetheless, given the recent evidence supporting a link between homocysteine and AMD, and other data suggesting an etiologic role for atherosclerosis and endothelial dysfunction in AMD 37 — 40it is reasonable to propose that homocysteine-lowering with folic acid and B vitamins may help to decrease risks of AMD.
At present, there are no previous data from large randomized trials to examine this hypothesis. Methods Study design WAFACS was a randomized, double-blind, placebo-controlled trial that evaluated whether a combination of folic acid, vitamin B6, and vitamin B12 could reduce cardiovascular events among women with preexisting CVD or 3 or more coronary risk factors 41 —